Structure of PDB 3kqn Chain A Binding Site BS01

Receptor Information
>3kqn Chain A (length=437) Species: 333284 (Hepatitis C virus (isolate Con1)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGF
GAYMSKAHGIDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIII
CDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEE
VALSSTGEIPFYGKAIPIETIKGGRHLIFCHSKKKCDELAAKLSGLGLNA
VAYYRGLDVSVIPTSGDVIVVATDALMTGFTGDFDSVIDCNTCVTQTVDF
SLDPTFTIETTTVPQDAVSRSQRRGRTGRGRMGIYRFVTPGERPSGMFDS
SVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTG
LTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRL
KPTLHGPTPLLYRLGAVQNEVTTTHPITKYIMACMSA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3kqn Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		V232 T254 G255 G271 K272 A275 D296 T298 R393 W501 Q552
Binding residue
(residue number reindexed from 1)		V44 T66 G67 G83 K84 A87 D108 T110 R205 W313 Q364
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:3kqn, PDBe:3kqn, PDBj:3kqn
PDBsum3kqn
PubMed20080715
UniProtQ9WMX2|POLG_HCVCO Genome polyprotein

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