Structure of PDB 3knr Chain A Binding Site BS01

Receptor Information
>3knr Chain A (length=214) Species: 1396 (Bacillus cereus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTISISQLNKNVWVHTELGSFNGEAVPSNGLVLNTSKGLVLVDSSWDDKL
TKELIEMVEKKFQKRVTDVIITHAHADRIGGIKTLKERGIKAHSTALTAE
LAKKNGYEEPLGDLQTVTNLKFGNMKVETFYPGKGHTEDNIVVWLPQYNI
LVGGDLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHGEV
GDKGLLLHTLDLLK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3knr Chain A Residue 228 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3knr Metallo-beta-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions.
Resolution1.71 Å
Binding residue
(original residue number in PDB)		H86 H88 H149
Binding residue
(residue number reindexed from 1)		H73 H75 H136
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H86 H88 D90 H149 D168 K171 N180 H210
Catalytic site (residue number reindexed from 1) H73 H75 D77 H136 D155 K158 N167 H197
Enzyme Commision number 3.5.2.6: beta-lactamase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3knr, PDBe:3knr, PDBj:3knr
PDBsum3knr
PubMed22729148
UniProtP04190|BLA2_BACCE Metallo-beta-lactamase type 2 (Gene Name=blm)

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