Structure of PDB 3knd Chain A Binding Site BS01

Receptor Information
>3knd Chain A (length=428) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAG
LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFIS
LLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLS
TLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLA
DSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGN
IVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQ
IQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC
GIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGG
LDKIEALQRHENESVYKASLNLIEKYFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3knd Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha.
Resolution2.151 Å
Binding residue
(original residue number in PDB)		S105 W142 N146 A148 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 D270 W273 G281 R315 V321 T322 W357 N361 E396 W399
Binding residue
(residue number reindexed from 1)		S36 W73 N77 A79 S80 G81 T86 Q112 W115 N119 G122 D123 W162 R169 D201 W204 G212 R246 V252 T253 W288 N292 E327 W330
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3knd, PDBe:3knd, PDBj:3knd
PDBsum3knd
PubMed20335181
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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