Structure of PDB 3kms Chain A Binding Site BS01

Receptor Information
>3kms Chain A (length=476) Species: 12116 (Foot and mouth disease virus C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKSDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH
Ligand information
Receptor-Ligand Complex Structure
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PDB3kms Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R17 K20 L108 D109 T115 A116 R128 F162 K164 D165 V181 R193 H204 G216 C217 N218 G299 C300 S301 Y336 R416
Binding residue
(residue number reindexed from 1)		R17 K20 L108 D109 T115 A116 R128 F162 K164 D165 V181 R193 H204 G216 C217 N218 G299 C300 S301 Y336 R416
Enzymatic activity
Enzyme Commision number 3.4.22.46: L-peptidase.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3kms, PDBe:3kms, PDBj:3kms
PDBsum3kms
PubMed20392853
UniProtQ9QCE3

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