Structure of PDB 3kmq Chain A Binding Site BS01

Receptor Information

>3kmq Chain A (length=476) Species: 12116 (Foot and mouth disease virus C)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKSDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH

Ligand information

>3kmq Chain B (length=5)

gggcc

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3kmq Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
• Resolution: 2.11 Å
• Binding residue (original residue number in PDB): L108 D109 M111 E112 R128 R193 H204 G216 C217 N218 S301 A302 T303 Y336
• Binding residue (residue number reindexed from 1): L108 D109 M111 E112 R128 R193 H204 G216 C217 N218 S301 A302 T303 Y336

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:3kmq, PDBe:3kmq, PDBj:3kmq
• PDBsum: 3kmq
• PubMed: 20392853
• UniProt: Q9QCE3