Structure of PDB 3kmd Chain A Binding Site BS01

Receptor Information

>3kmd Chain A (length=200) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTC
PVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPP
QHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSS
CMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRK

Ligand information

>3kmd Chain E (length=19) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gggcatgcctaggcatgcc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3kmd Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
Resolution	2.15 Å
Binding residue (original residue number in PDB)	S241 R248 R273 C275 R280
Binding residue (residue number reindexed from 1)	S150 R157 R182 C184 R189

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:3kmd, PDBe:3kmd, PDBj:3kmd
PDBsum	3kmd
PubMed	20159469
UniProt	P04637\|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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