Structure of PDB 3klv Chain A Binding Site BS01

Receptor Information
>3klv Chain A (length=476) Species: 12116 (Foot and mouth disease virus C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKSDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGIPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH
Ligand information
Receptor-Ligand Complex Structure
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PDB3klv Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
Resolution2.6 Å
Binding residue
(original residue number in PDB)		L108 D109 T115 A116 R128 F162 K164 D165 V181 I189 R193 H204 G216 C217 N218 G299 C300 A302 T303
Binding residue
(residue number reindexed from 1)		L108 D109 T115 A116 R128 F162 K164 D165 V181 I189 R193 H204 G216 C217 N218 G299 C300 A302 T303
Enzymatic activity
Enzyme Commision number 3.4.22.46: L-peptidase.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3klv, PDBe:3klv, PDBj:3klv
PDBsum3klv
PubMed20392853
UniProtQ9QCE3

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