Structure of PDB 3kl8 Chain A Binding Site BS01

Receptor Information
>3kl8 Chain A (length=256) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNYDVKEEVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ
HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQ
ILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEA
WHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQH
RLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVP
WICNRE
Ligand information
>3kl8 Chain F (length=17) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KRPPKLGQIGRSKRVVI
Receptor-Ligand Complex Structure
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PDB3kl8 Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.
Resolution3.372 Å
Binding residue
(original residue number in PDB)		Q68 P70
Binding residue
(residue number reindexed from 1)		Q50 P52
Enzymatic activity
Catalytic site (original residue number in PDB) N135 K137 E139 N140 D156 T175
Catalytic site (residue number reindexed from 1) N117 K119 E121 N122 D138 T157
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3kl8, PDBe:3kl8, PDBj:3kl8
PDBsum3kl8
PubMed20139983
UniProtO62305|KCC2D_CAEEL Calcium/calmodulin-dependent protein kinase type II (Gene Name=unc-43)

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