Structure of PDB 3kl4 Chain A Binding Site BS01

Receptor Information

>3kl4 Chain A (length=412) Species: 273057 (Saccharolobus solfataricus P2)

GLENIRDAVRKFLTGSTPYEKAVDEFIKDLQKSLISSDVNVKLVFSLTAK
IKERLNKEKPPSVLERKEWFISIVYDELSKLFGGDKEPNVNPTKLPFIIM
LVGVQGSGKTTTAGKLAYFYKKRGYKVGLVAADVYRPAAYDQLLQLGNQI
GVQVYGEPNNQNPIEIAKKGVDIFVKNKMDIIIVDTAGRHGYGEETKLLE
EMKEMYDVLKPDDVILVIDASIGQKAYDLASRFHQASPIGSVIITKMDGT
AKGGGALSAVVATGATIKFIGTGEKIDELETFNAKRFVSRILGMGDIESI
LEKVKGLLTLRDVYAQIIALRKMGPLSKVLQHIPGLGIMLPTPSEDQLKI
GEEKIRRWLAALNSMTYKELENPNIIDKSRMRRIAEGSGLEVEEVRELLE
WYNNMNRLLKMV

Ligand information

>3kl4 Chain B (length=20) Species: 4932 (Saccharomyces cerevisiae)

GIILVLLIWGTVLLLKSIPH

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3kl4 Recognition of a signal peptide by the signal recognition particle.
• Resolution: 3.5 Å
• Binding residue (original residue number in PDB): Q335 R375 E413 E416 W420 V431
• Binding residue (residue number reindexed from 1): Q316 R356 E394 E397 W401 V412

Enzymatic activity

• Enzyme Commision number: 3.6.5.4: signal-recognition-particle GTPase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0008312 7S RNA binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006612 protein targeting to membrane
• GO:0006614 SRP-dependent cotranslational protein targeting to membrane

Cellular Component

• GO:0005737 cytoplasm
• GO:0048500 signal recognition particle

External links

• PDB: RCSB:3kl4, PDBe:3kl4, PDBj:3kl4
• PDBsum: 3kl4
• PubMed: 20364120
• UniProt: Q97ZE7|SRP54_SACS2 Signal recognition particle 54 kDa protein (Gene Name=srp54)