Structure of PDB 3kfh Chain A Binding Site BS01

Receptor Information
>3kfh Chain A (length=152) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LNVEKINGEWFSILLASDKREKIEEHGSMRVFVEHIHVLENSLAFKFHTV
IDGECSEIFLVADKTEKAGEYSVMYDGFNTFTILKTDYDNYIMFHLINEK
DGKTFQLMELYGRKADLNSDIKEKFVKLCEEHGIIKENIIDLTKTNRCLK
AR
Ligand information
Ligand ID2EH
InChIInChI=1S/C8H18O/c1-3-5-6-8(4-2)7-9/h8-9H,3-7H2,1-2H3/t8-/m0/s1
InChIKeyYIWUKEYIRIRTPP-QMMMGPOBSA-N
SMILES
SoftwareSMILES
CACTVS 3.352
OpenEye OEToolkits 1.7.0		CCCC[C@H](CC)CO
OpenEye OEToolkits 1.7.0CCCCC(CC)CO
CACTVS 3.352CCCC[CH](CC)CO
FormulaC8 H18 O
Name(2S)-2-ethylhexan-1-ol
ChEMBL
DrugBank
ZINCZINC000001529452
PDB chain3kfh Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3kfh High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones.
Resolution1.02 Å
Binding residue
(original residue number in PDB)		M38 V40 F103 E118
Binding residue
(residue number reindexed from 1)		M29 V31 F94 E109
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005009 insulin receptor activity
GO:0005515 protein binding
GO:0005550 pheromone binding
GO:0036094 small molecule binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007005 mitochondrion organization
GO:0008286 insulin receptor signaling pathway
GO:0009060 aerobic respiration
GO:0010628 positive regulation of gene expression
GO:0010888 negative regulation of lipid storage
GO:0010907 positive regulation of glucose metabolic process
GO:0031649 heat generation
GO:0042593 glucose homeostasis
GO:0045475 locomotor rhythm
GO:0045721 negative regulation of gluconeogenesis
GO:0045834 positive regulation of lipid metabolic process
GO:0045892 negative regulation of DNA-templated transcription
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0071396 cellular response to lipid
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kfh, PDBe:3kfh, PDBj:3kfh
PDBsum3kfh
PubMed20509168
UniProtP11590|MUP4_MOUSE Major urinary protein 4 (Gene Name=Mup4)

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