Structure of PDB 3kfg Chain A Binding Site BS01

Receptor Information
>3kfg Chain A (length=152) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LNVEKINGEWFSILLASDKREKIEEHGSMRVFVEHIHVLENSLAFKFHTV
IDGECSEIFLVADKTEKAGEYSVMYDGFNTFTILKTDYDNYIMFHLINEK
DGKTFQLMELYGRKADLNSDIKEKFVKLCEEHGIIKENIIDLTKTNRCLK
AR
Ligand information
Ligand ID2EH
InChIInChI=1S/C8H18O/c1-3-5-6-8(4-2)7-9/h8-9H,3-7H2,1-2H3/t8-/m0/s1
InChIKeyYIWUKEYIRIRTPP-QMMMGPOBSA-N
SMILES
SoftwareSMILES
CACTVS 3.352
OpenEye OEToolkits 1.7.0		CCCC[C@H](CC)CO
OpenEye OEToolkits 1.7.0CCCCC(CC)CO
CACTVS 3.352CCCC[CH](CC)CO
FormulaC8 H18 O
Name(2S)-2-ethylhexan-1-ol
ChEMBL
DrugBank
ZINCZINC000001529452
PDB chain3kfg Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3kfg High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones.
Resolution1.43 Å
Binding residue
(original residue number in PDB)		M38 V40 F54 L69 L116 E118
Binding residue
(residue number reindexed from 1)		M29 V31 F45 L60 L107 E109
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005009 insulin receptor activity
GO:0005515 protein binding
GO:0005550 pheromone binding
GO:0036094 small molecule binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007005 mitochondrion organization
GO:0008286 insulin receptor signaling pathway
GO:0009060 aerobic respiration
GO:0010628 positive regulation of gene expression
GO:0010888 negative regulation of lipid storage
GO:0010907 positive regulation of glucose metabolic process
GO:0031649 heat generation
GO:0042593 glucose homeostasis
GO:0045475 locomotor rhythm
GO:0045721 negative regulation of gluconeogenesis
GO:0045834 positive regulation of lipid metabolic process
GO:0045892 negative regulation of DNA-templated transcription
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0071396 cellular response to lipid
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kfg, PDBe:3kfg, PDBj:3kfg
PDBsum3kfg
PubMed20509168
UniProtP11590|MUP4_MOUSE Major urinary protein 4 (Gene Name=Mup4)

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