Structure of PDB 3kf2 Chain A Binding Site BS01

Receptor Information
>3kf2 Chain A (length=154) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTN
VDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLL
SPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLET
TMRS
Ligand information
Receptor-Ligand Complex Structure
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PDB3kf2 Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
Resolution2.5 Å
Binding residue
(original residue number in PDB)		V29 G31 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65 P88 G90
Binding residue
(residue number reindexed from 1)		V2 G4 E5 V6 Q7 I8 V9 S10 R35 T36 I37 A38 P61 G63
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H30 D54 G110 S112
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3kf2, PDBe:3kf2, PDBj:3kf2
PDBsum3kf2
PubMed20166108
UniProtB2Y2M9

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