Structure of PDB 3k5m Chain A Binding Site BS01

Receptor Information
>3k5m Chain A (length=768) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHMAQAGFILTRHWRDTPQGTEVSFWLATDNGPLQVTLAPQESVAFIPAD
QVPRAQHILQGEQGFRLTPLALKDFHRQPVYGLYCRAHRQLMNYEKRLRE
GGVTVYEADVRPPERYLMERFITSPVWVEGDMHNGTIVNARLKPHPDYRP
PLKWVSIDIETTRHGELYCIGLEGCGQRIVYMLGPENGDASSLDFELEYV
ASRPQLLEKLNAWFANYDPDVIIGWNVVQFDLRMLQKHAERYRLPLRLGR
DNSELEWREHKNGFFAQAKGRLIIDGIEALKSAFWNFSSFSLETVAQELL
GEGSIDNPWDRMDEIDRRFAEDKPALATYNLKNCELVTQIFHKTEIMPFL
LERATVNGLPVDRHGGSVAAFGHLYFPRMHRAGYVAPNLGEVPPHASPGG
YVMDSRPGLYDSVLVLDYKSLYPSIIRTFLIDPVGLVEGMAQPDPEHSTE
GFLDAWFSREKHCLPEIVTNIWHGRDEAKRQGNKPLSQALKIIMNAFYGV
LGTTACRFFDPRLASSITMRGHQIMRQTKALIEAQGYDVIYGDTDSTFVW
LKGAHSEEEAAKIGRALVQHVNAWWAETLQKQRLTSALELEYETHFCRFL
MPTIRGADTGSKKRYAGLIQEGDKQRMVFKGLETVRTDWTPLAQQFQQEL
YLRIFRNEPYQEYVRETIDKLMAGELDARLVYRKRLRRPLSEYQRNVPPH
VRAARLADEENQKRGRPLQYQNRGTIKYVWTTNGPEPLDYQRSPLDYEHY
LTRQLQPVAEGILPFIED
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3k5m Structural insight into translesion synthesis by DNA Pol II.
Resolution2.04 Å
Binding residue
(original residue number in PDB)		H258 F266 R365 S369 V370 A398 S399 P400 G401 G501 T505 A507 I606 R607 K614 K615 R616 R638 N698 R755 P759
Binding residue
(residue number reindexed from 1)		H260 F265 R363 S367 V368 A396 S397 P398 G399 G499 T503 A505 I604 R605 K612 K613 R614 R636 N696 R753 P757
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008296 3'-5'-DNA exonuclease activity
Biological Process
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0009432 SOS response
GO:0045004 DNA replication proofreading
GO:0071897 DNA biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3k5m, PDBe:3k5m, PDBj:3k5m
PDBsum3k5m
PubMed20064374
UniProtP21189|DPO2_ECOLI DNA polymerase II (Gene Name=polB)

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