Structure of PDB 3k42 Chain A Binding Site BS01

Receptor Information

>3k42 Chain A (length=141) Species: 9913 (Bos taurus)

EKTCDLVGESEKQLALLKRLTPLFQKSFESTVGQSPDMYSYVFRVCREAG
QHSSGAGLVQIQKSNGKETVVGRFNETQIFQGSNWIMLIYKGGDEYDNHC
GREQRRAVVMISCNRHTLADNFNPVSECFYLFEMDSSLACS

Ligand information

• Ligand ID: 1GP
• InChI: InChI=1S/C3H9O6P/c4-1-3(5)2-9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)/t3-/m0/s1
• InChIKey: AWUCVROLDVIAJX-VKHMYHEASA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C(COP(=O)(O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H](COP(=O)(O)O)O)O
  ACDLabs 10.04: O=P(O)(O)OCC(O)CO
  CACTVS 3.341: OC[CH](O)CO[P](O)(O)=O
  CACTVS 3.341: OC[C@H](O)CO[P](O)(O)=O
• Formula: C3 H9 O6 P
• Name: SN-GLYCEROL-1-PHOSPHATE
• ZINC: ZINC000003830895
• PDB chain: 3k42 Chain A Residue 7000

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3k42 Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): F34 E35 D126 N127 F128
• Binding residue (residue number reindexed from 1): F28 E29 D120 N121 F122
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0019904 protein domain specific binding

Biological Process

• GO:0006622 protein targeting to lysosome

Cellular Component

• GO:0005768 endosome
• GO:0005794 Golgi apparatus

External links

• PDB: RCSB:3k42, PDBe:3k42, PDBj:3k42
• PDBsum: 3k42
• PubMed: 19928875
• UniProt: P11456|MPRD_BOVIN Cation-dependent mannose-6-phosphate receptor (Gene Name=M6PR)