Structure of PDB 3k2u Chain A Binding Site BS01

Receptor Information
>3k2u Chain A (length=233) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDS
VSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKG
DRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDVSGYSSSLREALV
PLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGV
AYLYGIISWGCLHKPGVYTRVANYVDWINDRIR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3k2u Unraveling the allosteric mechanism of serine protease inhibition by an antibody.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		S26 W29 R114 P120 I121 C122 A207
Binding residue
(residue number reindexed from 1)		S11 W14 R106 P112 I113 C114 A201
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D90 Q186 G187 D188 S189 G190
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3k2u, PDBe:3k2u, PDBj:3k2u
PDBsum3k2u
PubMed20004165
UniProtQ04756|HGFA_HUMAN Hepatocyte growth factor activator (Gene Name=HGFAC)

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