Structure of PDB 3k24 Chain A Binding Site BS01

Receptor Information
>3k24 Chain A (length=220) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APRSVDWREKGYVTPVKNQGQCGSAWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVK
MAKDRRNHCGIASAASYPTV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3k24 Structural basis for the recognition and cleavage of histone H3 by cathepsin L.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		G23 A25 G67 G68 M70 A135
Binding residue
(residue number reindexed from 1)		G23 A25 G67 G68 M70 A135
Enzymatic activity
Catalytic site (original residue number in PDB) Q19 A25 H163 N187
Catalytic site (residue number reindexed from 1) Q19 A25 H163 N187
Enzyme Commision number 3.4.22.15: cathepsin L.
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3k24, PDBe:3k24, PDBj:3k24
PDBsum3k24
PubMed21326229
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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