Structure of PDB 3k22 Chain A Binding Site BS01
Receptor Information
>3k22 Chain A (length=250) Species:
9606
(Homo sapiens) [
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PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSANLLCFAPD
LIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVP
KDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMH
EVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
Ligand information
>3k22 Chain H (length=11) Species:
9606
(Homo sapiens) [
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ENALLRYLLDK
Receptor-Ligand Complex Structure
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PDB
3k22
Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
V575 K579 L589 M593 M752 E755
Binding residue
(residue number reindexed from 1)
V50 K54 L64 M68 M226 E229
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:3k22
,
PDBe:3k22
,
PDBj:3k22
PDBsum
3k22
PubMed
19822747
UniProt
P04150
|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)
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