Structure of PDB 3k1l Chain A Binding Site BS01

Receptor Information
>3k1l Chain A (length=376) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDVERLLCQKYPGLAAELQPSGACIIRGVLGSEDTWRRLKLYLPHHPALH
GFQLYVQESLEYKLYTSANLKLQDDWLLEDFLDHLPKILPAQKAPTVPEL
CREGNIYYDILALYKSNEYCLQVDEACSMIRFSEFTDFEQHYLELKIPSL
LLLDHSLPDCVSLGEMLTKSAGNLEEALNLFRKLLEDLRPFYDNFMDIDE
LCHVLQPSPISSKHKTRLFPLKDRVYLKLTIADPFACIASMSLKIIGPTE
EVARLRHVLSDGLSNWDSEMNIHKNLLRMFDLCYFPMPDWSDGPKLDEED
NEELRCNICFAYRLDGGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKT
FLEVSFGQCPFCKAKLSTSFAALLND
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain3k1l Chain D Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3k1l The structure of the catalytic subunit FANCL of the Fanconi anemia core complex
Resolution3.2 Å
Binding residue
(original residue number in PDB)		M292 D294 S296
Binding residue
(residue number reindexed from 1)		M287 D289 S291
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0016567 protein ubiquitination
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0043240 Fanconi anaemia nuclear complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3k1l, PDBe:3k1l, PDBj:3k1l
PDBsum3k1l
PubMed20154706
UniProtQ8T913|FANCL_DROME E3 ubiquitin-protein ligase Fancl (Gene Name=Fancl)

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