Structure of PDB 3k0k Chain A Binding Site BS01

Receptor Information

>3k0k Chain A (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE
RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQG
PKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSF
TLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQ
ELDTYLIPQIP

Ligand information

>3k0k Chain B (length=4) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SPTF

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3k0k Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Resolution	2.7 Å
Binding residue (original residue number in PDB)	S1655 G1656 R1699 K1702 N1774 M1775
Binding residue (residue number reindexed from 1)	S7 G8 R51 K54 N126 M127

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006281	DNA repair
GO:0006974	DNA damage response

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:3k0k, PDBe:3k0k, PDBj:3k0k
PDBsum	3k0k
PubMed	20159462
UniProt	P38398\|BRCA1_HUMAN Breast cancer type 1 susceptibility protein (Gene Name=BRCA1)

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