Structure of PDB 3jwr Chain A Binding Site BS01

Receptor Information
>3jwr Chain A (length=323) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ
NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQN
KLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHF
DQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFF
ELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEF
WEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTQLYEALTHVS
EDCFPLLDGCRKNRQKWQALAEQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3jwr Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
Resolution2.994 Å
Binding residue
(original residue number in PDB)		Q666 H678 A726 I802 G819 F823
Binding residue
(residue number reindexed from 1)		Q130 H142 A190 I266 G283 F287
Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3jwr, PDBe:3jwr, PDBj:3jwr
PDBsum3jwr
PubMed19798052
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A);
P51160

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