Structure of PDB 3jpx Chain A Binding Site BS01

Receptor Information

>3jpx Chain A (length=359) Species: 9606 (Homo sapiens)

SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQG
EIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFG
GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY
NPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVC
WKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALG
NQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCD
DASIWRWDR

Ligand information

>3jpx Chain B (length=6) Species: 9606 (Homo sapiens)

HRKVLR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3jpx Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): F97 Y148 N307 C324 D362 I363 W364 Y365 R414
• Binding residue (residue number reindexed from 1): F17 Y68 N227 C244 D282 I283 W284 Y285 R334

Gene Ontology

Molecular Function

• GO:0001222 transcription corepressor binding
• GO:0003682 chromatin binding
• GO:0005515 protein binding
• GO:0008047 enzyme activator activity
• GO:0031491 nucleosome binding
• GO:0042802 identical protein binding

Biological Process

• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0006325 chromatin organization
• GO:0021510 spinal cord development
• GO:0031507 heterochromatin formation
• GO:0045892 negative regulation of DNA-templated transcription

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0005829 cytosol
• GO:0035098 ESC/E(Z) complex

External links

• PDB: RCSB:3jpx, PDBe:3jpx, PDBj:3jpx
• PDBsum: 3jpx
• PubMed: 20974918
• UniProt: O75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)