Structure of PDB 3jca Chain A Binding Site BS01

Receptor Information
>3jca Chain A (length=262) Species: 11757 (Mouse mammary tumor virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALESAQESHALHHQNAAALRFQFHITREQAREIVKLCPNCPHAPQLGVNP
RGLKPRVLWQMDVTHVSEFGKLKYVHVTVDTYSHFTFATARTGEATKDVL
QHLAQSFAYMGIPQKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYNPQG
QAIVERTHQNIKAQLNKLQKAGKYYTPHHLLAHALFVLNHVNMDNQGHTA
AERHWGPISADPKPMVMWKDLLTGSWKGPDVLITAGRGYACVFPQDAESP
IWVPDRFIRPFT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3jca Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		G50 V51 N52 P53 R54 H87 K120 G146 I147 Q152 R159
Binding residue
(residue number reindexed from 1)		G47 V48 N49 P50 R51 H84 K117 G143 I144 Q149 R156
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3jca, PDBe:3jca, PDBj:3jca
PDBsum3jca
PubMed26887496
UniProtP03365|POL_MMTVB Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)

[Back to BioLiP]