Structure of PDB 3jb9 Chain A Binding Site BS01

Receptor Information
>3jb9 Chain A (length=1964) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEKQLNERARKWRASQKSKFGVKRKQGYVQTEKADLPPEHLRKIMKDRGD
MSSRKFRADKRSYLGALKYLPHAVLKLLENMPMPWEEYREVKVLYHVTGA
ITFVNESPRVIEPHFIAQWGTMWMMMRREKRDRKNFKRLRFPPFDDEEPP
FSIDQLLDLEPLEAIRMDLDEEDDAPVMDWFYENKALEDTPHVNGPTYRR
WKLNLPQMANLHRLGYQLLSDLRDDNYFYLFNDNSFFTAKALNVAIPGGP
KFEPLYEFNDIYKLIIRHPIKTEYRIAFPYLYNSRARSVALSEYHQPSNV
FVPPEDPDLPAFFWDPIINPITSRQLTLHELDTSPEDSAIEEDPNFEIPF
DPFFHSEDIEFEHTASALILLWAPHPFNKRSGATKRAQDVPLIKHWYLEH
CPPNQPVKVRVSYQKLLKSHVMNKLHMAHPKSHTNRSLLRQLKNTKFFQS
TSIDWVEAGLQVCRQGYNMLQLLIHRKGLTYLHLDYNCNLKPTKTLTTKE
RKKSRFGNAFHLMREILRLTKLIVDSHVQYRLGNIDAYQLADGLHYIFNH
VGQLTGMYRYKYRLMRQIRACKDFKHLIYYRFNTGPVGKGPGCGFWAPSW
RVWLFFLRGIVPLLERWLGNLLARQFEGRHSTGVAKQITKQRVDSHQDLE
LRAAVMNDILDMIPEGIRQGKSKTILQHLSEAWRCWKANIPWKVPGLPAP
IENMILRYVKSKADWWTSVAHFNRERIRRGATVDKTVAKKNLGRLTRLWL
KAEQERQHNYLKDGPYVTADEAVAIYTTFVHWLESRRFQPIPFPPLSYKH
DTKLLVLALERLKEAYSVKGRLNQSQREELALVEQAYDNPHEMLSQIKRR
LLTMRTFKEVGIEFMDMYSHLIPVYSVDPMEKICDAYLDQYLWFEADRRH
LFPSWVKPSDSEPPPLLVYKWCQGINNLTDVWETSNGECNVLMETRLSKV
FEKVDLTLLNRLMSLLMDTNLASYASAKNNVVLSYKDMSHTNSYGLVRGL
QFSSFIWQFYGLVLDLLILGLQRATEIAGPADAPNDFLHFKDQATETSHP
IRLYTRYIDKVYIMFRFTDEESRDLIQRFLNENPDPTNSNVVNYSKGKKN
CWPRDARMRLMKHDVNLGRAVFWEIRNRLPRSLTTLEWEDTFPSVYSKDN
PNLLFSMTGFEVRILPKIRQNEEFSLKDGVWNLTDNRTKQRTAQAFIRVT
EDGINQFGNRIRQILMSSGSTTFTKIANKWNTALIALMTYYREAAISTPE
LLDLLVKCESKIQTRVKISLNSKMPSRFPPAVFYSPKELGGLGMLSMGHV
LIPQSDLRWSKQTDTGITHFRSGMTTNGEHLIPNLYRYIQPWESEFIDSQ
RVWAEYAMKRQEALQQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYD
KGWRVRTEFKQYQLLKNNPFWWTSQRHDGKLWQLNNYRVDVIQALGGVEG
ILEHTMFKATGFPSWEGLFWEKASGFKKLTNAQRSGLNQIPNRRFTLWWS
PTINRANVYVGFQVQLDLTGIMMHGKIPTLKISLIQIFRSHLWQKIHESV
VWDLCQVLDQELESLQIETVQKETIHPRKSYKMNSSCADILLLAAYKWNV
SRPSLLNDNRDVLDNTTTNKYWIDVQLRFGDYDSHDIERYTRAKFLDYST
DAQSMYPSPTGVLIGIDLCYNMHSAYGNWIPGMKPLIQQSMNKIMKANPA
LYVLRERIRKGLQLYASEQYLSSSNYAELFSNQIQLFVDDTNVYRVTIHK
TFEGNLTTKPINGAIFIFNPRTGQLFLKVIHTSVWAGQKRLGQLAKWKTA
EEVAALIRSLPVEEQPRQIIVTRKGMLDPLEVHLLDFPNITIKGSELQLP
FQAIIKLDKINDLILRATEPQMVLFNLYDDWLQSVSSYTAFSRLILILRA
LNVNTEKTKLILRPDKSIITKENHVWPNLDDQQWLDVEPKLRDLILADYA
KKNNINVASLTNSE
Ligand information
>3jb9 Chain C (length=105) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgucaaagcacuuugcaaaagcuaacguaucuguuucuugccuuuuacca
gaaacagccguuuguaaggugugcuaauuugacuguauaguuuuuguaau
cuuuu
.<<<<<<<<<<<<<<<<<<...........<<<<<<<<.<.......>.>
>>>>>>>...>>>>>>>>>>>>.....>>>>>>.................
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3jb9 Structure of a yeast spliceosome at 3.6-angstrom resolution
Resolution3.6 Å
Binding residue
(original residue number in PDB)		K69 Q76 E78 R155 G241 P242 T243 R245 K286 F298 E299 L301 H432 R443 D446 K451 K475 N480 K481 H483 H486 P487 K488 S489 H490 N492 R497 K618 Y619 R620 R658 F662 R665 G666 P669 V790 D791 K1318
Binding residue
(residue number reindexed from 1)		K23 Q30 E32 R109 G195 P196 T197 R199 K240 F252 E253 L255 H375 R386 D389 K394 K418 N423 K424 H426 H429 P430 K431 S432 H433 N435 R440 K561 Y562 R563 R601 F605 R608 G609 P612 V733 D734 K1261
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004843 cysteine-type deubiquitinase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030623 U5 snRNA binding
GO:0097157 pre-mRNA intronic binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000393 spliceosomal conformational changes to generate catalytic conformation
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071013 catalytic step 2 spliceosome
GO:0071014 post-mRNA release spliceosomal complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3jb9, PDBe:3jb9, PDBj:3jb9
PDBsum3jb9
PubMed26292707
UniProtO14187|SPP42_SCHPO Pre-mRNA-splicing factor spp42 (Gene Name=spp42)

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