Structure of PDB 3j5y Chain A Binding Site BS01

Receptor Information

>3j5y Chain A (length=414) Species: 9606 (Homo sapiens)

AADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEF
GTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEGK
EKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGA
LFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVA
ETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDI
SYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVE
DTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKSH
FTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKGF
GGIGGILRYRVDFQ

Ligand information

>3j5y Chain C (length=10)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 3j5y Structure of the mammalian ribosomal pre-termination complex associated with eRF1*eRF3*GDPNP.
• Resolution: 9.7 Å
• Binding residue (original residue number in PDB): T58 N61 I62 K63 S64
• Binding residue (residue number reindexed from 1): T52 N55 I56 K57 S58

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003747 translation release factor activity
• GO:0004045 aminoacyl-tRNA hydrolase activity
• GO:0005515 protein binding
• GO:0008079 translation termination factor activity
• GO:0016149 translation release factor activity, codon specific
• GO:0043022 ribosome binding
• GO:1990825 sequence-specific mRNA binding

Biological Process

• GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
• GO:0002184 cytoplasmic translational termination
• GO:0006412 translation
• GO:0006415 translational termination
• GO:0006449 regulation of translational termination
• GO:0006479 protein methylation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0018444 translation release factor complex
• GO:0022626 cytosolic ribosome

External links

• PDB: RCSB:3j5y, PDBe:3j5y, PDBj:3j5y
• PDBsum: 3j5y
• PubMed: 24335085
• UniProt: P62495|ERF1_HUMAN Eukaryotic peptide chain release factor subunit 1 (Gene Name=ETF1)