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Receptor Information

>3j2q Chain A (length=630) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ATRRYYLGAVELSWDYVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQ
AEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDK
VFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALL
VCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSSARAWPKMHTVNGYVNR
SLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISP
ITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPKHPKTWV
HYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTD
ETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDV
RPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYY
SSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENR
SWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHE
VAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSME
NPGLWILGCHNSDFRNRGMTALLKVSSCDK

Ligand ID

InChI

InChI=1S/Cu/q+2

InChIKey

JPVYNHNXODAKFH-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Cu+2]
CACTVS 3.341	[Cu++]

Formula

Name

COPPER (II) ION

PDB chain

3j2q Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3j2q Domain organization of membrane-bound factor VIII.
Resolution	15.0 Å
Binding residue (original residue number in PDB)	H267 C310 H315
Binding residue (residue number reindexed from 1)	H227 C270 H275
Annotation score	3

Enzyme Commision number

	Molecular Function
GO:0005507	copper ion binding

PDB	RCSB:3j2q, PDBe:3j2q, PDBj:3j2q
PDBsum	3j2q
PubMed	23616213
UniProt	P00451\|FA8_HUMAN Coagulation factor VIII (Gene Name=F8)

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Structure of PDB 3j2q Chain A Binding Site BS01