Structure of PDB 3iur Chain A Binding Site BS01

Receptor Information

>3iur Chain A (length=668) Species: 648 (Aeromonas caviae)

LHYPVTRQGEQVDHYFGQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYL
AQIPYRAAIKEKLAASWNYAKEGAPFREGRYHYFFKNDGLQNQNVLWRQQ
EGKPAEVFLDPNTLSPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHL
MDVESKQPLETPLKDVKFSGISWLGNEGFFYSSYDKPTDQHKVYFHRLGT
AQEDDRLVFGAIPAQHHRYVGATVTEDDRFLLISAANSTSGNRLYVKDLS
QENAPLLTVQGDLDADVSLVDNKGSTLYLLTNRDAPNRRLVTVDAANPGP
AHWRDLIPERQQVLTVHSGSGYLFAEYMVDATARVEQFDYEGKRVREVAL
PGLGSVSGFNGKHDDPALYFGFENYAQPPTLYRFEPKSGAISLYRASAAP
FKPEDYVSEQRFYQSKDGTRVPLIISYRKGLKLDGSNPTILYGYGGFDVS
LTPSFSVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTQQNKQNVFDDF
IAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMRVALPAVGV
LDMLRYHTFTAGTGWAYDYGTSADSEAMFDYLKGYSPLHNVRPGVSYPST
MVTTADHNDRVVPAHSFKFAATLQADNAGPHPQLIRIETPVAKLIEQSAD
IYAFTLYEMGYRELPRQP

Ligand information

>3iur Chain B (length=6)

MTRSAF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3iur Induced-fit mechanism for prolyl endopeptidase
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): N296 P300 N301 D462 Y494
• Binding residue (residue number reindexed from 1): N282 P286 N287 D448 Y480

Enzymatic activity

• Catalytic site (original residue number in PDB): Y458 S538 N622
• Catalytic site (residue number reindexed from 1): Y444 S524 N608
• Enzyme Commision number: 3.4.21.26: prolyl oligopeptidase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0016787 hydrolase activity
• GO:0070012 oligopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:3iur, PDBe:3iur, PDBj:3iur
• PDBsum: 3iur
• PubMed: 20444688
• UniProt: Q9X6R4