Structure of PDB 3i3w Chain A Binding Site BS01

Receptor Information
>3i3w Chain A (length=441) Species: 119856 (Francisella tularensis subsp. tularensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYFGTDGIRGEVANSTITVEFTQKLGNAVGSLINQKNYPKFVIVGQDTRS
SGGFLKFALVSGLNAAGIDVLDLGVVPTPVVAFMTVKHRAAAGFVITASH
NKFTDNGIKLFSSNGFKLDDALEEEVEDMIDGDFIYQPQFKFGSYKILAN
AIDEYIESIYSRFAKFVNYKGKVVVDCAHGAASHNFEALLDKFGINYVSI
ASNPDGLNINVGCGATCVSNIKKAVKEQKADLGISLDGDADRIIIVDENG
QEIDGDGILNILAQYSDICGGTNGIVGTQMTNMSYENHYRANKIPFIRSK
VGDRYVLEDLVKYGYKIGGESSGHVINLNFGTTGDGLFTAIQLLAIFSQA
DKPVSEFKLQGELMQQTLINVPLTKKVAREDLQKVASDVNDVEKRLGNRG
RVLLRPSGTEPVLRVMVEADDKSLATNEAEYLVEKVKQKLV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3i3w Chain A Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3i3w Structure of a phosphoglucosamine mutase from Francisella tularensis
Resolution2.3 Å
Binding residue
(original residue number in PDB)		S101 D239 D241 D243
Binding residue
(residue number reindexed from 1)		S99 D237 D239 D241
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) R11 S101 H102 K111 D239 D241 D243 R244 H326
Catalytic site (residue number reindexed from 1) R9 S99 H100 K109 D237 D239 D241 R242 H324
Enzyme Commision number 5.4.2.10: phosphoglucosamine mutase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004615 phosphomannomutase activity
GO:0008966 phosphoglucosamine mutase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3i3w, PDBe:3i3w, PDBj:3i3w
PDBsum3i3w
PubMed
UniProtQ5NII8|GLMM_FRATT Phosphoglucosamine mutase (Gene Name=glmM)

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