Structure of PDB 3hxq Chain A Binding Site BS01

Receptor Information
>3hxq Chain A (length=201) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWV
RVAVVEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYT
LFQIFSKIDRPEASRIALLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPV
GIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEA
P
Ligand information
>3hxq Chain B (length=41) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcgtgcagtgccttcggccgtgcggtgcctccgtcacgcc
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hxq A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1.
Resolution2.694 Å
Binding residue
(original residue number in PDB)		R524 F603 Q625 E626 P627 Q628 R629 S631 R632 N633 R636 Y637 L659 K660
Binding residue
(residue number reindexed from 1)		R23 F102 Q124 E125 P126 Q127 R128 S130 R131 N132 R135 Y136 L158 K159
Binding affinityPDBbind-CN: Kd=0.6nM
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:3hxq, PDBe:3hxq, PDBj:3hxq
PDBsum3hxq
PubMed19913482
UniProtP04275|VWF_HUMAN von Willebrand factor (Gene Name=VWF)

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