Structure of PDB 3hxm Chain A Binding Site BS01

Receptor Information
>3hxm Chain A (length=637) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRAG
GVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDPG
ERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLD
LWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWEL
LRLGEEDPSLLDYHASKGRVPVLTLEDLHEALSLPWEERRRRTREIASWI
GRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALA
LLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRK
AKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRW
ENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGG
GHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGR
VPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLED
KTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFA
FPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hxm Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		A170 Y171 R172 I173 Y226 H227 L281 M413 K422 Q433 I434 L435 N436 R446 N449 K457 R580 T613 R615 P650 R651 H657 R661
Binding residue
(residue number reindexed from 1)		A166 Y167 R168 I169 Y213 H214 L234 M366 K375 Q386 I387 L388 N389 R399 N402 K410 R532 T565 R567 P602 R603 H609 R613
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3hxm, PDBe:3hxm, PDBj:3hxm
PDBsum3hxm
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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