Structure of PDB 3hwt Chain A Binding Site BS01

Receptor Information
>3hwt Chain A (length=319) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIG
KRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQG
FRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAF
NSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGF
LTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYF
TGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGAKVGPGRVLPTPTE
KDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hwt Scrunching during DNA repair synthesis
Resolution1.95 Å
Binding residue
(original residue number in PDB)		W274 L277 V462 S463 Q464 Q471 K472 H511 R514 R517 K521 L527 S528 E529 H530 H541
Binding residue
(residue number reindexed from 1)		W18 L21 V206 S207 Q208 Q215 K216 H255 R258 R261 K265 L271 S272 E273 H274 H285
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D171 D173 D234
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3hwt, PDBe:3hwt, PDBj:3hwt
PDBsum3hwt
PubMed
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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