Structure of PDB 3hvr Chain A Binding Site BS01

Receptor Information
>3hvr Chain A (length=660) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPLPLSLLDYHASKGRLQGREGGRVAWVADKPIPHTGL
LVPVLTLEDLSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIP
KLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAF
GASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRN
RLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAY
PAELAVGFDAGGRESFRFGGAACAVGGHLLWTLPEAQAGERIPQEVVWDL
LEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAYDLVS
VRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRGTPRPLKLVHEAGD
TPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGIRHLK
EVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
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PDB3hvr Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Resolution3.211 Å
Binding residue
(original residue number in PDB)		R172 I173 T201 M413 R418 K422 Q433 I434 N436 H445 R446 N449 E512 R513 R580 R651 R661 V685
Binding residue
(residue number reindexed from 1)		R170 I171 T199 M394 R399 K403 Q414 I415 N417 H426 R427 N430 E490 R491 R558 R626 R636 V660
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3hvr, PDBe:3hvr, PDBj:3hvr
PDBsum3hvr
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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