Structure of PDB 3hrz Chain A Binding Site BS01

Receptor Information
>3hrz Chain A (length=614) Species: 8649 (Naja kaouthia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALYTLITPAVLRTDTEEQILVEAHGDSTPKQLDIFVHDFPRKQKTLFQTR
VDMNPAGGMLVTPTIEIPAKEVSTDNQYVVVQVTGPQVRLEKVVLLSYQS
SFLFIQTDKGIYTPGSPVLYRVFSMDHTVIVEFQTPEGILVSSNSVDLNF
FWPYNLPDLVSLGTWRIVAKYEHSPENYTAYFDVRKYVLPSFEVRLQPSE
KFFYIDGNENFHVSITARYLYGEEVEGVAFVLFGVKIDDAKKSIPDSLTR
IPIIDGDGKATLKRDTFRSRFPNLNELVGHTLYASVTVMTESGSDMVVTE
QSGIHIVASPYQIHFTKTPKYFKPGMPYELTVYVTNPDGSPAAHVPVVSE
AFHSMGTTLSDGTAKLILNIPLNAQSLPITVRTNHGDLPRERQATKSMTA
IAYQTQGGSGNYLHVAITSTEIKPGDNLPVNFNVKGNANSLKQIKYFTYL
ILNKGKIFKVGRQPRRDGQNLVTMNLHITPDLIPSFRFVAYYQVGNNEIV
ADSVWVDVKDTCMGTLVVKGDNLIQMPGAAMKIKLEGDPGARVGLVAVDK
AVYVLNDKYKISQAKIWDTIEKSDFGCTAGSGQNNLGVFEDAGLALTTST
NLNTKQRSAAKCPQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3hrz Chain A Residue 628 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hrz Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex
Resolution2.2 Å
Binding residue
(original residue number in PDB)		P494 D517 V518 D520
Binding residue
(residue number reindexed from 1)		P484 D507 V508 D510
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004866 endopeptidase inhibitor activity

View graph for
Molecular Function
External links
PDB RCSB:3hrz, PDBe:3hrz, PDBj:3hrz
PDBsum3hrz
PubMed19574954
UniProtQ91132|VCO3_NAJKA Cobra venom factor

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