Structure of PDB 3hqu Chain A Binding Site BS01

Receptor Information
>3hqu Chain A (length=215) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTD
GQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKL
GSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAK
VSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAIT
VWYFDADERARAKVK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hqu Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D277 R281 N293 G294 R295 K297 F391 R396 K400
Binding residue
(residue number reindexed from 1)		D90 R94 N106 G107 R108 K110 F204 R209 K213
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:3hqu, PDBe:3hqu, PDBj:3hqu
PDBsum3hqu
PubMed19604478
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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