Structure of PDB 3ho1 Chain A Binding Site BS01

Receptor Information
>3ho1 Chain A (length=673) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVAR
RAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPK
DPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGA
VLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRT
WELLRLGEEDPKELSLLDYHASKGRLQGREGGRVAWVADPKKPIPHLTGL
LVPVLTLEDLHEEEGSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVR
AQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEF
LRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLT
PPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGL
QVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGGHLLWTLPEAQAGE
RIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRNGRVPQDEFALALEALA
REGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRG
TPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRL
VKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ho1 Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		A170 Y171 R172 I173 R192 Y197 R200 Y226 H227 R232 I254 P255 L265 L267 L279 R286 M413 K422 Q433 I434 L435 N436 R446 N449 R580 T613 R615 P650 R651 H657 V685
Binding residue
(residue number reindexed from 1)		A169 Y170 R171 I172 R191 Y196 R199 Y219 H220 R225 I244 P245 L255 L257 L269 R276 M403 K412 Q423 I424 L425 N426 R436 N439 R568 T601 R603 P638 R639 H645 V673
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3ho1, PDBe:3ho1, PDBj:3ho1
PDBsum3ho1
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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