Structure of PDB 3hmf Chain A Binding Site BS01

Receptor Information
>3hmf Chain A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMSPAYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIK
EPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANS
IKKIFYMKKAEIEHHE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3hmf Chain A Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3hmf Histone recognition and large-scale structural analysis of the human bromodomain family.
Resolution1.63 Å
Binding residue
(original residue number in PDB)		H290 E291
Binding residue
(residue number reindexed from 1)		H115 E116
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0016586 RSC-type complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3hmf, PDBe:3hmf, PDBj:3hmf
PDBsum3hmf
PubMed22464331
UniProtQ86U86|PB1_HUMAN Protein polybromo-1 (Gene Name=PBRM1)

[Back to BioLiP]