Structure of PDB 3hko Chain A Binding Site BS01

Receptor Information

>3hko Chain A (length=319) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LYFQGGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNK
IRQKDVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLL
DKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGSIFRESLDFVQREK
LISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSK
EFYKLNNGAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPF
PGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAM
RALQHPWISQFSDKIYKMS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

3hko Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3hko Crystal structure of a cdpk kinase domain from cryptosporidium Parvum, cgd7_40
Resolution	1.8 Å
Binding residue (original residue number in PDB)	H93 C122 C124 C127
Binding residue (residue number reindexed from 1)	H95 C124 C126 C129
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	D175 K177 N180 D195 T219
Catalytic site (residue number reindexed from 1)	D175 K177 N180 D195 T211
Enzyme Commision number	2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:3hko, PDBe:3hko, PDBj:3hko
PDBsum	3hko
PubMed
UniProt	Q5CZ29

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