Structure of PDB 3hk2 Chain A Binding Site BS01

Receptor Information
>3hk2 Chain A (length=664) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVL
DLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWE
LLRLGEEDPKELPLPSLLDYHASKGRLQGREGGRVAWVADPKDPRKPIPH
LTGLLVPVLTLELPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSI
PKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRA
FGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDR
NRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGA
YPAELAVGFNAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEV
VWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIAY
DLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRGTPRPLKLVH
EAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGI
RHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hk2 Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y43 A170 Y171 R172 T266 R286 M413 W415 K422 Q433 I434 N436 R446 N449 E512 R513 R548 P550 Q551 R580 T613 R615 A644 S645 R651 H657 R661 V685
Binding residue
(residue number reindexed from 1)		Y40 A167 Y168 R169 T260 R268 M395 W397 K404 Q415 I416 N418 R428 N431 E494 R495 R530 P532 Q533 R562 T592 R594 A623 S624 R630 H636 R640 V664
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3hk2, PDBe:3hk2, PDBj:3hk2
PDBsum3hk2
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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