Structure of PDB 3hjf Chain A Binding Site BS01

Receptor Information
>3hjf Chain A (length=665) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKEGLSLLDYHASKGRLQGREGGRVAWVADPKDPRKPIPHL
TGLLVPVLTLEDLSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRL
SIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALL
RAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWE
DRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALS
GAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQ
EVVWDLLEETLWAFRRKAGRLPSRVLLLREGRVPQDEFALALEALAREGI
AYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVRGTPRPLKLV
HEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLG
IRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hjf Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Resolution3.056 Å
Binding residue
(original residue number in PDB)		Y43 P44 A170 Y171 R172 P412 M413 W415 R418 K422 Q433 I434 N436 R446 N449 G511 P550 R580 T613 R615 A644 A648 R651 H657 R661
Binding residue
(residue number reindexed from 1)		Y41 P42 A168 Y169 R170 P396 M397 W399 R402 K406 Q417 I418 N420 R430 N433 G495 P534 R564 T593 R595 A624 A628 R631 H637 R641
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3hjf, PDBe:3hjf, PDBj:3hjf
PDBsum3hjf
PubMed19812667
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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