Structure of PDB 3h87 Chain A Binding Site BS01

Receptor Information
>3h87 Chain A (length=136) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECG
EIARREFREPPLSAMPVEYLTPRIEDRALEVQTLLADRGHHRGPSIPDLL
IAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3h87 Chain A Residue 159 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3h87 The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg(2+) ion in the active site and a putative RNA-binding site.
Resolution1.49 Å
Binding residue
(original residue number in PDB)		D99 D117 D119
Binding residue
(residue number reindexed from 1)		D98 D116 D118
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004518 nuclease activity
GO:0004540 RNA nuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:3h87, PDBe:3h87, PDBj:3h87
PDBsum3h87
PubMed23011806
UniProtP9WFB9|VAPC2_MYCTU Ribonuclease VapC2 (Gene Name=vapC2)

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