Structure of PDB 3h7v Chain A Binding Site BS01

Receptor Information

>3h7v Chain A (length=320) Species: 197221 (Thermosynechococcus vestitus BP-1)

LRWQWRIYEEPLQEPLTTAQGVWRSRSGIYLRLEDEQGQVGYGEIAPLPG
WGSETLNADIALCQQLPGHLTPEIMATIPEALPAAQFGFATAWQSVGRLP
YRVRPWPICALLGSGQAALEQWQQSWQRGQTTFKWKVGVMSPEEEQAILK
ALLAALPPGAKLRLDANGSWDRATANRWFAWLDRHGNGKIEYVEQPLPPD
QWQALLSLAQTVTTAIALDESVVSAAEVQRWVDRGWPGFFVIKTALFGDP
DSLSLLLRRGLEPQRLVFSSALEGAIARTAIFHLLETWQPCHALGFGVDR
WRSAPLLTTLTAYERLWERL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3h7v Chain A Residue 331

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3h7v Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): D165 E194 D219
• Binding residue (residue number reindexed from 1): D165 E194 D219
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): K134 K136 D165 E194 D219 K243
• Catalytic site (residue number reindexed from 1): K134 K136 D165 E194 D219 K243
• Enzyme Commision number: 4.2.1.113: o-succinylbenzoate synthase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003824 catalytic activity
• GO:0016829 lyase activity
• GO:0016836 hydro-lyase activity
• GO:0043748 O-succinylbenzoate synthase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009234 menaquinone biosynthetic process
• GO:0042372 phylloquinone biosynthetic process

External links

• PDB: RCSB:3h7v, PDBe:3h7v, PDBj:3h7v
• PDBsum: 3h7v
• PubMed: 24872444
• UniProt: Q8DJP8|MENC_THEVB o-succinylbenzoate synthase (Gene Name=menC)