Structure of PDB 3h4b Chain A Binding Site BS01

Receptor Information
>3h4b Chain A (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLG
VKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLG
FDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLL
VGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPE
SCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELG
ISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEEL
LASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQVMTP
MVDILMKLFRNMTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB3h4b Replication across template T/U by human DNA polymerase-iota.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		L123 E127 K207 G241 G243 K245 T246 S359
Binding residue
(residue number reindexed from 1)		L99 E103 K183 G217 G219 K221 T222 S335
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3h4b, PDBe:3h4b, PDBj:3h4b
PDBsum3h4b
PubMed19604477
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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