Structure of PDB 3h1w Chain A Binding Site BS01

Receptor Information
>3h1w Chain A (length=390) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASMQKLINSVQNYAWGSKTALTELYGIANPQQQPMAELWMGAHPKSSSRI
TGETVSLRDAIEKNKTAMLGEAVANRFGELPFLFKVLCAAQPLSIQVHPN
KRNSEIGFAKENAAGIPMDAAERNYKDPNHKPELVFALTPFLAMNAFREF
SDIVSLLQPVAGAHSAIAHFLQVPNAERLSQLFASLLNMQGEEKSRALAV
LKAALNSQQGEPWQTIRVISEYYPDDSGLFSPLLLNVVKLNPGEAMFLFA
ETPHAYLQGVALEVMANSDNVLRAGLTPKYIDIPELVANVKFEPKPAGEL
LTAPVKSGAELDFPIPVDDFAFSLHDLALQETSIGQHSAAILFCVEGEAV
LRKDEQRLVLKPGESAFIGADESPVNASGTGRLARVYNKL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3h1w Chain A Residue 397 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3h1w Crystal structure of mannose 6-phosphate isomerase fromSalmonella typhimurium bound to metal atoms and substrate: Implications for catalytic mechanism
Resolution1.94 Å
Binding residue
(original residue number in PDB)		H99 E134 H255
Binding residue
(residue number reindexed from 1)		H98 E133 H254
Annotation score1
Enzymatic activity
Enzyme Commision number 5.3.1.8: mannose-6-phosphate isomerase.
Gene Ontology
Molecular Function
GO:0004476 mannose-6-phosphate isomerase activity
GO:0008270 zinc ion binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009298 GDP-mannose biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3h1w, PDBe:3h1w, PDBj:3h1w
PDBsum3h1w
PubMed
UniProtP25081|MANA_SALTY Mannose-6-phosphate isomerase (Gene Name=manA)

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