Structure of PDB 3god Chain A Binding Site BS01

Receptor Information

>3god Chain A (length=320) Species: 208963 (Pseudomonas aeruginosa UCBPP-PA14)

DISPSELKTILHSKRANLYYLQHCRVLVNGGRVEYVTDEGRHSHYWNIPI
ANTTSLLLGTGTSITQAAMRELARAGVLVGFCGGGGTPLFSANEVDVEVS
WLTPQSEYRPTEYLQRWVGFWFDEEKRLVAARHFQRARLERIRHSWLEDR
VLRDAGFAVDATALAVAVEDSARALEQAPNHEHLLTEEARLSKRLFKLAA
QATRYGEFVRAKRGSGGDPANRFLDHGNYLAYGLAATATWVLGIPHGLAV
LHGKTRRGGLVFDVADLIKDSLILPQAFLSAMRGDEEQDFRQACLDNLSR
AQALDFMIDTLKDVAQRSTV

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 3god Chain A Residue 325

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3god Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense.
• Resolution: 2.17 Å
• Binding residue (original residue number in PDB): E190 H254 D268
• Binding residue (residue number reindexed from 1): E188 H252 D266
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0004519 endonuclease activity
• GO:0004520 DNA endonuclease activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0043571 maintenance of CRISPR repeat elements
• GO:0051607 defense response to virus

External links

• PDB: RCSB:3god, PDBe:3god, PDBj:3god
• PDBsum: 3god
• PubMed: 19523907
• UniProt: Q02ML7|CAS1_PSEAB CRISPR-associated endonuclease Cas1 (Gene Name=cas1)