Structure of PDB 3g10 Chain A Binding Site BS01

Receptor Information
>3g10 Chain A (length=252) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPIRDVWSTNLQQEMNLIMSLIERYPVVSMDTEFPGVVARPLGVFKSSDD
YHYQTLRANVDSLKIIQIGLALSDEEGNAPVEACTWQFNFTFNLQDDMYA
PESIELLTKSGIDFKKHQEVGIEPADFAELLIGSGLVLQEEVTWITFHSG
YDFAYLLKAMTQIPLPAEYEEFYKILCIYFPKNYDIKYIMKSVLNNSKGL
QDIADDLQIHRIGPQHQAGSDALLTARIFFEIRSRYFDGSIDSRMLNQLY
GL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3g10 Chain A Residue 333 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3g10 The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active site
Resolution2.597 Å
Binding residue
(original residue number in PDB)		D50 E52
Binding residue
(residue number reindexed from 1)		D31 E33
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0004527 exonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0004540 RNA nuclease activity
GO:0008270 zinc ion binding
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006402 mRNA catabolic process
GO:0031047 regulatory ncRNA-mediated gene silencing
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3g10, PDBe:3g10, PDBj:3g10
PDBsum3g10
PubMed19307292
UniProtO74856|CAF1_SCHPO Poly(A) ribonuclease pop2 (Gene Name=caf1)

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