Structure of PDB 3fnt Chain A Binding Site BS01

Receptor Information
>3fnt Chain A (length=323) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNVELKDLANVLSFGEAKLGDNGQKFNFLFHTASSNVWVPSIKCTSESCE
SKNHYDSSKSKTYEKDDTPVKLTSKAGTISGIFSKDLVTIGKLSVPYKFI
EMTEIVGFEPFYSESDVDGVFGLGWKDLSIGSIDPYIVELKTQNKIEQAV
YSIYLPPENKNKGYLTIGGIEERFFDGPLNYEKLNHDLMWQVDLDVHFGN
VSSKKANVILDSATSVITVPTEFFNQFVESASVFKVPFLSLYVTTCGNTK
LPTLEYRSPNKVYTLEPKQYLEPLENIFSALCMLNIVPIDLEKNTFVLGD
PFMRKYFTVYDYDNHTVGFALAK
Ligand information
>3fnt Chain I (length=6) Species: 285516 (Streptomyces argenteolus subsp. toyonakensis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VVVLAL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3fnt Crystal structures of the histo-aspartic protease (HAP) from plasmodium falciparum.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		H32 K76 D215 A217 T218 S219 L291
Binding residue
(residue number reindexed from 1)		H31 K75 D211 A213 T214 S215 L291
Enzymatic activity
Catalytic site (original residue number in PDB) H32 S35 N37 W39 S75 D215 T218
Catalytic site (residue number reindexed from 1) H31 S34 N36 W38 S74 D211 T214
Enzyme Commision number 3.4.23.39: plasmepsin II.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3fnt, PDBe:3fnt, PDBj:3fnt
PDBsum3fnt
PubMed19285084
UniProtQ8IM15|PLM3_PLAF7 Plasmepsin III (Gene Name=PMIII)

[Back to BioLiP]