Structure of PDB 3fht Chain A Binding Site BS01

Receptor Information
>3fht Chain A (length=392) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALP
LMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYEL
ALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDW
CSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFS
ATFEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDEKFQAL
CNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAA
VIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYL
HRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3fht The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner
Resolution2.2 Å
Binding residue
(original residue number in PDB)		P170 T171 Y172 R199 K202 L203 T217 G219 T220 D223 K227 F230 H253 Q256 H341 T342 R343 G365 R372 T390 V392
Binding residue
(residue number reindexed from 1)		P96 T97 Y98 R125 K128 L129 T143 G145 T146 D149 K153 F156 H179 Q182 H267 T268 R269 G291 R298 T316 V318
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:3fht, PDBe:3fht, PDBj:3fht
PDBsum3fht
PubMed19219046
UniProtQ9UMR2|DD19B_HUMAN ATP-dependent RNA helicase DDX19B (Gene Name=DDX19B)

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