Structure of PDB 3fhd Chain A Binding Site BS01

Receptor Information
>3fhd Chain A (length=456) Species: 435895 (Human herpesvirus 8 type M) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PADLFSEDYLVDTLDGLTVDDQQAVLASLSFSKFLKHAKVRDWCAQAKIQ
PSMPALRMAYNYFLFSKVGEFIGSEDVCNFFVDRVFGGVRLLDVASVYAA
CSQMNAHQRHHICCLVERATSSQSLNPVWDALRDGIISSSKFHWAVKQQN
TSKKIFSPGLRCEEVVKTLLATLLHPDETNCLDYGFMQSPQNGIFGVSLD
FAANVKTDTEGRLQFDPNCKVYEIKCRFKYTFAKMECDPIYAAYQRLYEA
PGKLALKDFFYSISKPAVEYVGLGKLPSESDYLVAYDQEWEACRKLTPLH
NLIRECILHNSTTESDVYVLTDPQDTRGQISIKARFKANLFVNVRHSYFY
QVLLQSSIVEEYIGLDSGIPRLGSPKYYIATGFFRKRGYQDPVNCTIGGD
ALDPHVEIPTLLIVTPVYFPRGAKHRLLHQAANFWSRSAKDTFPYIKWDF
SYLSAN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3fhd Chain A Residue 490 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3fhd Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi's sarcoma-associated herpesvirus
Resolution1.85 Å
Binding residue
(original residue number in PDB)		E184 D221 E244 I245
Binding residue
(residue number reindexed from 1)		E163 D200 E223 I224
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:3fhd, PDBe:3fhd, PDBj:3fhd
PDBsum3fhd
PubMed19843164
UniProtP88925

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