Structure of PDB 3f9r Chain A Binding Site BS01

Receptor Information

>3f9r Chain A (length=246) Species: 5691 (Trypanosoma brucei)

GMKRVLLLFDVDGTLTPPRLCQTDEMRALIKRARGAGFCVGTVGGSDFAK
QVEQLGRDVLTQFDYVFAENGLLAYRNGLEIHRQSLLNALGNDRIVKFVK
KTLRLIADLDIPVQRGTFVEYRNGMINVSPIGRNCSQAERDEFEVYDNEH
RVRASLIAELENSFPDFGLKYSIGGQISFDVFPVGWDKTYCLQFVEDDFE
EIHFFGDKTQEGGNDYEIYTDKRTIGHKVTSYKDTIAEVEKIIAMK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3f9r Chain A Residue 248

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3f9r Crystal Structure of Trypanosoma Brucei phosphomannosemutase, TB.10.700.370
• Resolution: 1.85 Å
• Binding residue (original residue number in PDB): Y219 T220 D221 T224
• Binding residue (residue number reindexed from 1): Y219 T220 D221 T224
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.4.2.8: phosphomannomutase.

Gene Ontology

Molecular Function

• GO:0004615 phosphomannomutase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006013 mannose metabolic process
• GO:0006487 protein N-linked glycosylation
• GO:0009298 GDP-mannose biosynthetic process
• GO:0019307 mannose biosynthetic process

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0020015 glycosome
• GO:0097014 ciliary plasm

External links

• PDB: RCSB:3f9r, PDBe:3f9r, PDBj:3f9r
• PDBsum: 3f9r
• UniProt: Q38AW2