Structure of PDB 3euz Chain A Binding Site BS01

Receptor Information
>3euz Chain A (length=119) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETAAAKFERQHMDSSSSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQ
AVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKH
IIVACEGNPYVPVHFDASV
Ligand information
Ligand IDDMF
InChIInChI=1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
InChIKeyZMXDDKWLCZADIW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CN(C)C=O
ACDLabs 10.04O=CN(C)C
FormulaC3 H7 N O
NameDIMETHYLFORMAMIDE
ChEMBLCHEMBL268291
DrugBankDB01844
ZINCZINC000000901648
PDB chain3euz Chain A Residue 905 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3euz Multiple solvent crystal structures of ribonuclease A: An assessment of the method
Resolution1.84 Å
Binding residue
(original residue number in PDB)		N62 V63 A64 T70
Binding residue
(residue number reindexed from 1)		N57 V58 A59 T65
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H12 K41 H119 F120 D121
Catalytic site (residue number reindexed from 1) H11 K36 H114 F115 D116
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3euz, PDBe:3euz, PDBj:3euz
PDBsum3euz
PubMed19291738
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

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