Structure of PDB 3et3 Chain A Binding Site BS01

Receptor Information
>3et3 Chain A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSL
MMGEDKIKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP
LLQEIYKDLY
Ligand information
Receptor-Ligand Complex Structure
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PDB3et3 Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent
Resolution1.95 Å
Binding residue
(original residue number in PDB)		K301 N312 V315 T316 L318 K319 P467 L468 E471
Binding residue
(residue number reindexed from 1)		K84 N95 V98 T99 L101 K102 P250 L251 E254
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3et3, PDBe:3et3, PDBj:3et3
PDBsum3et3
PubMed19116277
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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